Molecular Pathways: Fatty Acid Synthase
نویسندگان
چکیده
منابع مشابه
Molecular Pathways Molecular Pathways: Fatty Acid Synthase
Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) e...
متن کاملMolecular Pathways: Fatty Acid Synthase.
Therapies that target tumor metabolism represent a new horizon in anticancer therapies. In particular, cancer cells are dependent on the generation of lipids, which are essential for cell membrane synthesis, modification of proteins, and localization of many oncogenic signal transduction enzymes. Because fatty acids are the building blocks of these important lipids, fatty acid synthase (FASN) e...
متن کاملHuman fatty acid synthase: properties and molecular cloning.
Fatty acid synthase (FAS; EC 2.3.1.85) was purified to near homogeneity from a human hepatoma cell line, HepG2. The HepG2 FAS has a specific activity of 600 nmol of NADPH oxidized per min per mg, which is about half that of chicken liver FAS. All the partial activities of human FAS are comparable to those of other animal FASs, except for the beta-ketoacyl synthase, whose significantly lower act...
متن کاملFIRE (fatty acid synthase insulin-responsive element) and ICE (inverted CCAAT element) regulate fatty acid synthase.
Introduction Fatty acid synthase (FAS) plays a central role in de novo lipogenesis in mammals and birds by catalysing the reaction in the conversion of acetyl-CoA and malonyl-CoA into palmitate. FAS activity is not known to be regulated by allosteric effectors or covalent modifications. However, FAS concentration is exquisitely sensitive to nutritional, hormonal and developmental states [ 1-31....
متن کاملProtein interactions of fatty acid synthase II.
We have used a yeast two-hybrid approach to detect direct protein interactions between fatty acid synthase components. Enoyl-acyl carrier protein (ACP) reductase was found to interact with stearoyl-ACP desaturase and acyl-ACP thioesterase, but none of these proteins interacted with ACP in the yeast nucleus.
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2015
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-15-0126